THE INGREDIENTS
All of these theories are based on preliminary studies found in the published literature. In science rarely anything is truly "proven" and we learn new things every day. We strive to make quality products based on sound theories. LG Sciences is committed to making the best sports supplements on the market.
3betaHydroxy-Androst-5-Ene-17-One – is the prohormone component of M1D Black. This prohormone is often known as dehydroepiandrosterone however that name is misleading. We theorize when this prohormone is combined with the right cofactors it can boost testosterone and other key androgens which is what your body needs in addition to exercise and diet to get in shape especially in light of all of the environmental chemical disruptors. (1,2,3)
2-Phenyl-benzo{h}chromen-4-one - this natural anti-estrogen is extracted from passion flower and preliminary studies suugest that it is more potent than many other aromatase inhibitors. We believe, based on some preimiary studies, that the combination of 3betaHydroxy-Androst-5-Ene-17-One with an aromatase inhibitor will boost testosterone where others failed! (4,5)
L-Carnitine L-Tartarate - this amino acid salt has been shown in preliminary studies to increase the effects of the androgen receptor after intense exercise. This means that the increase in testosterone is amplified with LCLT. (6)
Cissus quandrangularis (Whole Plant extract) - this natural product has very good anecdotal reports of being a natural anabolic. Preliminary literature suggests it may inhibit cortisol and reduce inflammation. (7,8)
Stinging Nettle (Root Extract)- this natural extract is thought to reduce the enzyme 5aReductase and reduce SHBG activity. This will help prevent hair loss and also make androgens more potent by being more available. (9,10)
Phellodendron amurensis (Bark Extract) - this extract was shown in one initial study to be as potent as the ancillary drug tamoxifen at reducing the effects of estrogen. This natural (S)ERM is intended to reduce the estrogenic effects in the body.
Piperine- this ingredient has been shown to help the absorption of numerous dietary supplements. (11)
Luteolin - this ingredient is a natural blocker of enzymes that deactivate prohormones. we theorize it will help make our prohormone products more active.
1. Taylor MK, Padilla GA, Stanfill KE, Markham AE, Khosravi JY, Ward MD, Koehler MM. Stress. Effects of dehydroepiandrosterone supplementation during stressful military training: a randomized, controlled, double-blind field study. 2012 Jan;15(1):85-96. Epub 2011 Jul 26.
2. Speakman JR, O'Rahilly S. Fat: an evolving issue. Dis Model Mech. 2012 Sep;5(5):569-73.
3. Zhang X, Chang H, Wiseman S, He Y, Higley E, Jones P, Wong CK, Al-Khedhairy A, Giesy JP, Hecker M. Bisphenol A disrupts steroidogenesis in human H295R cells. Toxicol Sci. 2011 Jun;121(2):320-7. Epub 2011 Apr 6.
4. Dhawan K, Kumar S, Sharma A. Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats. J Med Food. 2002 Spring;5(1):43-8.
5. Kellis JT Jr, Vickery LE. Inhibition of human estrogen synthetase (aromatase) by flavones. Science. 1984 Sep 7;225(4666):1032-4.
6. Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exerc. 2006 Jul;38(7):1288-96.
7. Oben JE, Enyegue DM, Fomekong GI, Soukontoua YB, Agbor GA. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress. Lipids Health Dis. 2007 Feb 4;6:4.
8. Ross SM. Metabolic syndrome: a proprietary extract of Cissus quadrangularis formulation in the management of metabolic syndrome, weight loss, and central obesity. Holist Nurs Pract. 2012 Jul-Aug;26(4):228-30.
9. Nahata A, Dixit VK. Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats. Andrologia. 2012 May;44 Suppl 1:396-409. doi: 10.1111/j.1439-0272.2011.01197.x. Epub 2011 Aug 2.
10. Schöttner M, Gansser D, Spiteller G. Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG). Planta Med. 1997 Dec;63(6):529-32.
11. Johnson JJ, Nihal M, Siddiqui IA, Scarlett CO, Bailey HH, Mukhtar H, Ahmad N. Enhancing the bioavailability of resveratrol by combining it with piperine. Mol Nutr Food Res. 2011 Aug;55(8):1169-76. doi: 10.1002/mnfr.201100117. Epub 2011 Jun 29.